If you’ve been on LinkedIn or X recently, your feed is most likely full of posts about AI agents. Just yesterday OpenAI launched a few new tools for agents, including the Agents SDK.
In late November, Anthropic launched the Model Context Protocol (MCP). These two launches are really important in terms of reshaping how developers build agents and agentic applications.
In this guide, we’ll break down what these two tools do, how they compare, and how you can use them together.
OpenAI’s Agents SDK and Responses API
OpenAI’s newly launched Agents SDK is a lightweight (Python) framework for building AI agents that can plan, use tools, and execute multi-step tasks. In addition they also launched the Responses API.
- Responses API –
- A new API that brings together features from the Chat Completions API and the Assistants API.
- Biggest thing to highlight here is that it has three built-in tools
- OpenAI is signaling that this will be the endpoint that gets the most support and enhancements going forward
- Chat Completions is going to stay around and will get updates (not as many as Responses)
- Assistants API will be sunset in 2026.
- Built-in Tools – OpenAI released three built-in tools compatible with the Responses API
- Web Search: Real-time, cited search results - same search that powers ChatGPT
- File Search: Lets agents retrieve context files stored in your OpenAI vector store
- Computer Use (CUA): Agents can interact with a computer GUI - similar to Operator
- Agent-Orchestration Features – The SDK includes powerful features for structuring AI workflows:
- Handoffs: Agents can delegate specific tasks to sub-agents or specialized functions. For example, a customer support agent can escalate a billing issue to a billing agent
- Guardrails: Developers can enforce constraints on agent behavior. For example, a healthcare AI agent can be restricted from making certain medical recommendations without a human review
- Observability & Debugging: The SDK includes built-in tracing tools to help developers monitor how agents reason, execute actions, and handle failures.

What is Anthropic’s Model Context Protocol (MCP)?
We briefly covered Anthropic’s Model Context Protocol (MCP) in our weekly Substack a few weeks ago. MCP is an open standard for connecting AI models to external data sources and tools. The goal? To make it easy for any AI system—not just Claude—to securely interact with proprietary knowledge bases, databases, and APIs.

How it works:
- MCP Servers: Connect to specific data sources (e.g., Slack, Notion, internal databases) and expose them via the protocol.
- MCP Clients: AI models inside applications (like Claude, Cursor, etc) that query these servers dynamically.
- Standardized Interface: Instead of writing custom integrations for each tool, developers can plug into a universal framework.
MCP is designed to be model-agnostic, meaning any AI system—whether Claude, GPT-4, or open-source models—can implement it. Anthropic sees MCP as a USB-C port for AI, enabling seamless access to external knowledge and services.
There are even marketplaces and app-store like websites for listing and discovering MCP servers like,Smithery and Glama.

Will OpenAI release its own version of MCP? Maybe. But right now, MCP is the best standardized solution we have.
Comparing OpenAI’s Agents SDK & Anthropic’s MCP
By no means are they substitutes, they work well together, but given their importance, here's a nice table.
How they work together
OpenAI’s Agents SDK and Anthropic’s MCP complement each other. OpenAI’s Agent SDK makes it easy to spin up agents, leveraging built in tooling, orchestration, and tracing from OpenAI. MCP makes it easy to access data from tools like databases, CRMs, etc.
For example, if you’re building an AI assistant for customer support, you might:
- Use OpenAI’s Agents SDK to orchestrate the conversation and tool usage.
- Integrate MCP to fetch account details from an internal database or Zendesk.
- Have the agent decide whether to escalate the request or resolve it autonomously.
The speed at which you can build agents with these two tools is insane.
Final thoughts
Currently we have a hard time differentiating between what's an agent, what's just a chatbot, and what's just a workflow. Either way, building all of these just became much easier. OpenAI’s Agents SDK simplifies agent orchestration for multi-agent systems, while Anthropic’s MCP streamlines data integration—a key factor in maximizing LLM performance (context is king!). Time to build!
